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KMID : 0861020170320050057
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Korea Journal of Herbology
2017 Volume.32 No. 5 p.57 ~ p.63
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Comparative Evaluation of Korean Medicine Well-matched with Pork through an Inhibition of Pancreatic Lipase
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Shin Mi-Rae
Kim Soo-Hyun
Lee Ah-Reum
Kim Kyeong-Jo
Kim Su-Ji
Lee Young-Cheol
Roh Seong-Soo
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Abstract
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Objectives：The aim of this study is to search Korean Medicine with the superior inhibitory effect of pancreatic lipase including a possibility as a well-matched sauce material with pork.
Methods：We chose 5 samples which have the potent inhibitory effect of pancreatic lipase enzyme among 9 samples. 5 samples were Glycyrrhizae rhizoma, Cinnamomi cortex, Ganoderma lucidum, Syzygium aromaticum, and Schisandra chinensis. Animals were divided into eight groups (n =7). The experimental groups except for normal group were fed 60% high-fat diet. 5 samples were orally administered at a dose of 200 ㎎/㎏ body weight and orlistat were orally administrated at a dose of 60 ㎎/㎏ body weight for 7 days. Biochemical anaylses of 5 samples were executed based on lipid parameters such as triglyceride (TG) and total cholesterol (TC).
Results：Korean Medicines with IC50 of below 1 ㎎/㎖ were Glycyrrhizae rhizoma, Cinnamomi cortex, Ganoderma lucidum, Syzygium aromaticum, and Schisandra chinensis. Body weight change of all drug-treated groups except Glycyrrhizae rhizoma reduced significantly during the experimental period. Orlistat treatment reduced significantly both TG and TC in serum. The significant emission of TG in fece showed in Cinnamomi cortex treatment, whereas Ganoderma lucidum and Syzygium aromaticum showed a tendency to increase without a significance. Besides, Ganoderma lucidum and Schisandra chinensis emitted significantly TC to fece.
Conclusions：In conclusion, Cinnamomi cortex may exert anti-obesity effect by directly inhibiting pancreatic lipase, which would prevent the absorption of lipid from the small intestine. Accordingly, Cinnamomi cortex may suggest a high possibility as a well-matched sauce material with pork.
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KEYWORD
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Pork, Pancreatic lipase, Cinnamomi cortex, High fat diet
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